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學術報告|白血病干細胞功能穩態調控機制研究
公布的時間日期:2021-04-06 瀏覽次數:  資訊來自:動物火狐體育平臺

提題:兒童白血病干上皮細胞功用穩定調節作用機理學習主講人人:張好建

時間:2020年4月8日(星期四)上午9:30

區域:活力地理學學習中心站2018擴大多功能會議室連續人:于舒洋            連續形式:62733810

主講人簡介

張好建,現為武漢大學免疫與代謝前沿科學中心/醫學研究院教授,博士生導師。入選第十一批國家高層次人才青年項目,現主持國家自然科學基金優秀青年基金。

主要科研方問:造血干神經元功能模塊達到的調空火狐體育網頁版機制、兒童癌癥發病基本原理、兒童癌癥干神經元干性皮膚達到及抗藥性的氧分子基本原理等層面的探究。以第一點或通訊網絡做者在Cell Stem Cell (2016; 2020),Nature Genetics,Blood等雜志期刊說出多頁文獻資料。曾收獲2020年哈弗高中華人華僑研發者自己生物醫學工程課突出科研獎、201一年新加坡Leukemia & Lymphoma Society Fellow獎 。意味著論著:
  1. Mengdie Feng#, Xueqin Xie#, Guoqiang Han#, Tiantian Zhang, Yashu Li, Yicun Li, Rong Yin, Qifan Wang, Tong Zhang, Peipei Wang, Jin Hu, Ying Cheng, Zhuying Gao, Jing Wang, Jiwei Chang, Manman Cui, Kexin Gao, Jihua Chai, Weidong Liu, Chengli Guo, Shaoguang Li, Lingbo Liu, Fuling Zhou, Jianjun Chen, Haojian Zhang*. YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner. Blood. 2021 (IF= 17.543)
  2. Jiazhen Wang#,Yicun Li#, Peipei Wang#, Guoqiang Han#, Tiantian Zhang, Jiwei Chang, Rong Yin, Yi Shan, Jin Wen, Xueqin Xie, Mengdie Feng, Qifan Wang, Jin Hu, Ying Cheng, Tong Zhang, Yashu Li, Zhuying Gao, Chengli Guo, Jiang Wang, Jianfei Liang, Manman Cui, Kexin Gao, Jihua Chai, Weidong Liu, Hui Cheng, Lei Li, Fuling Zhou, Lingbo Liu, Yi Luo, Shaoguang Li, Haojian Zhang* Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. Cell Stem Cell. 2020 (IF= 20.86)
  3. Haojian Zhang, David Kozono, Kevin O’Connor, Sofia Vidal-Cardenas, Alix Rousseau, Abigail Hamilton, Lisa Moreau, Emily Gaudiano, Joel Greenberger, Grover Bagby, Jean Soulier, Markus Grompe, Kalindi Parmar, Alan D. D’Andrea*. TGF-β Inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia. Cell Stem Cell. 2016 (IF= 20.86)
  4. Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia Miron, Xueqing Zhang, Michael A Brehm, Dongguang Li, Michael R Green, Shaoguang Li*. Tumor suppressor role of the Blk pathway in cancer stem cells of chronic myeloid leukemia. Nature Genetics. 2012 (IF= 27.603)
  5. Haojian Zhang, Huawei Li, Hualin S Xi, Shaoguang Li*. HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood. 2012 (IF=17.543)

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